In this paper, an algorithm is developed to reject time and spatially varying boundary disturbances from a multidimensional Kirchhoff plate via boundary control. The disturbance and control input are assumed to be matched. The active disturbance rejection control approach is adopted for developing the algorithm. A state feedback scheme is designed to estimate the disturbance based on an infinite number of ordinary differential equations obtained from the original multidimensional system using infinitely many time-dependent test functions. The proposed control law cancels the disturbance using its estimated value. All subsystems in the closed loop are shown to be asymptotically stable. Simulation results are presented to validate the theoretical conclusions and to exhibit the reduction in the peaking phenomenon due to the use of time varying gains instead of constant high gains.