Liquid-phase nitration of toluene was carried out using a silica supported Cs salt of phosphomolybdic acid (Cs2.5H0.5PMoO40) as catalyst with dilute nitric acid under mild conditions. The CS2.5H0.5PMoO40 particles with Keggintype structure were well dispersed on the surface of silica, and the catalysts exhibited strong acidity, which may be responsible for the high catalytic nitration activity. The effects of various parameters on nitration were tested, which included reaction temperature, reaction time, catalyst amount and reactants ratio. Under suitable conditions, the nitrations gave high toluene conversion (99.6%) and good mono-nitration selectivity. Compared to the conventional process, there was no other organic solvent or sulfuric acid used in the reaction system, which made it more environment-friendly. Moreover, the supported catalyst was proven to have excellent stability in the nitration process. (C) 2013 The Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.