Temperature dependent Raman scattering measurements were carried out to investigate the phonon behavior of thermoelectric Cu3SbSe3 nanoparticles. The anomalous behavior of phonon mode (A(g)) frequency with temperature indicates the possibility of a lattice instability related to the order disorder structural transition at 380 K. In the low temperature region (80-250 K) we found an asymmetric line shape of A(g) mode, which is analyzed and discussed in the light of phonon continuum Fano-interference effect. We have obtained the thermal conductivity (K) similar to 2.04 W/mK at room temperature. The change in thermal conductivity with temperature strongly correlates with the change in total anharmonicity of the Cu3SbSe3 lattice. (C) 2014 Elsevier B.V. All rights reserved.