Journal of the American Chemical Society, Vol.136, No.36, 12548-12551, 2014
From Racemic Alcohols to Enantiopure Amines: Ru-Catalyzed Diastereoselective Amination
A commercially available ruthenium(II) PNP-type pincer catalyst (Ru-Macho) promotes the formation of alpha-chiral tert-butanesulfinylamines from racemic secondary alcohols and Ellmans chiral tert-butanesulfinamide via a hydrogen borrowing strategy. The formation of alpha-chiral tert-butanesulfinylamines occurs in yields ranging from 31% to 89% with most examples giving >95.5 dr.