Most of industrial processes have dead-time phenomenon that will affect the process performance. Though there are some disturbance rejection methods for the process with dead-time, however, most of them may not work well for multiple periodic disturbance. In this paper, a novel periodic disturbance rejection controller is designed based on the Smith predictor platform for process with long dead-time. By adding two feedback loops and the online spectrum analysis, multiple periodic disturbances can be suppressed effectively in existence of long dead-time. The rigorous analysis is conducted to prove that the robust stability can be maintained. Finally, the effectiveness of the proposed controller is demonstrated in the process simulations and industrial experiment. (C) 2014 Elsevier Ltd. All rights reserved.