Leaks in pipelines can cause major incidents resulting in both human injuries and financial losses. Among the considerable leak detection and location methods, the Negative Pressure Wave (NPW) based method has been widely used in locating leaks in liquid pipelines. The NPW based method only monitors the pressure changes at two ends of a pipeline. But the pressure is apt to be fixed by the end equipment and the change of it induced by a small or slow leakage is too small to be detected, which limit the application of the NPW based method in these situations. This paper presents a novel leak location method based on integrated signal, which is a combination of the pressure and flow rate signals. The representation of the integrated signal is derived from the transient analysis of the leakage. For the change of the integrated signal induced by a leakage is larger than the pressure change and it is also unaffected by the end equipment, the proposed method can be used to detect and locate small or slow leakage in a pipeline and can also be used in pipelines which end pressures are fixed by some kinds of equipment. The validation of the proposed method also confirms its advantages. (C) 2014 Elsevier Ltd. All rights reserved.