Safety-related structures are designed to provide a safe environment for the occupants and equipment during and after earthquakes. This is due to the fact that any damage imposed to the systems might lead to catastrophic consequences. Seismic probabilistic risk assessment (SPRA) is a systematic approach for the quantification of the seismic risk. One of the crucial steps in this assessment is to determine the seismic capacity of the structures by fragility method. After a review of available methodologies, this article analyzes the seismic fragility for a typical power plant containment considering the effects of soil-structure interaction (SSI). The structure and underneath soil profile are analyzed as a unified model by the subtraction method. Two steps are considered for the assessment of seismic response: In the first step, a fixed-base hypothesis framework is implemented to the computational problem. The second step covers computations taking into account the SSI effects. Using the results of seismic response analysis and safety factor method, seismic fragility of the structure is computed and related fragility curves are developed. Finally, by comparing the fragility curves, the effects of SSI are quantified on the overall seismic risk. (C) 2014 Elsevier Ltd. All rights reserved.