Widespread detection of numerous micropollutants including aromatic pharmaceuticals in effluents of wastewater treatment plants has prompted much research aimed at efficiently eliminating these contaminants of environmental concerns. In the present work, a novel hybrid bioreactor (HBR) of cross-linked enzymes aggregates of laccase (CLEA-Lac) and polysulfone hollow fiber MF membrane was developed for the elimination of acetaminophen (ACT), mefenamic acid (MFA) and carbamazepine (CBZ) as model aromatic pharmaceuticals. The MF alone showed removals of the three drugs varying approximately from 50 to 90% over the course of 8 h in the filtrate of aqueous solution. Synergistic action of the MF and CLEA-Lac during operation achieved eliminations from aqueous solution of around 99%, nearly 100% and up to 85% for ACT, MFA and CBZ, respectively. Under continuous operation, the HBR demonstrated elimination rates of the drugs from filtered wastewater up to 93% after 72 h for CBZ and near complete elimination of ACT and MFA was achieved within 24 h of treatment. Concomitantly to the drugs eliminations in the wastewater, the CLEA-Lac exhibited 25% residual activity while being continuously recycled with no activity in the filtrate. Meanwhile, the filtrate flowrate showed only minor decline indicating limited fouling of the membrane. (C) 2014 Elsevier B.V. All rights reserved.