The experiment data on the solubility and metastable zone width (MSZW) of sodium dichromate dihydrate have been determined in the temperature range from (290.45 to 319.76) K using the conventional polythermal method by turbidity monitoring technique. Based on the solubility data, the dissolution enthalpy and entropy of sodium dichromate dihydrate were calculated by the vant Hoff equation. Two approaches were used to estimate the nucleation kinetics of sodium dichromate dihydrate from the MSZW data, the self-consistent Nyvlt-like equation and the novel equation of three-dimensional nucleation theory. The notable factors affecting MSZW of sodium dichromate dihydrate such as cooling rate, initial composition, stirring rate, and presence of seed particles have been evaluated in this paper. It was observed that the MSZW of sodium dichromate dihydrate has an obvious decrease with the increase of initial composition, rotation frequency of stirring, and the mass of seed particles, respectively. Nevertheless, the MSZW becomes wider by enhancing the cooling rate and the diameter of seed particles.