This study describes how a flame spray pyrolysis method was successfully used to synthesize PtRu catalysts supported by carbon agglomerates. Nearly spherical catalysts composed of metallic Pt and Ru with molar ratio of 1:1 were produced in the flame and their size was about 1.9 nm. X-ray diffraction measurements revealed that amorphous-like Ru was well mixed into the Pt crystalline lattices. Through cyclic voltammetry for methanol oxidation reaction and CO stripping, it was found that the electrochemical activities of the catalysts produced from this process are comparable to or slightly better than those of an equivalent commercial sample with the same composition. Copyright (C) 2014, Hydrogen Energy Publications, LLC. Published by Elsevier Ltd. All rights reserved.