In present contribution, a suitable rate of reaction for pure methanol with no water as feed over commercial catalyst of HZSM-5 at industrial conditions in methanol dehydration process is found. This second order rate of reaction shows good agreement with experimental data with R-2 of more than 90%. Modeling results are also revealed that the proposed rate of reaction predicts the behavior of process, properly and therefore, this rate equation is reliable and accurate for simulation. (C) 2014 Elsevier Ltd. All rights reserved.