The aim of this research is to numerically and experimentally study the flow and heat transfer characteristics of in-line impinging jets in cross-flow. The jets from a row of round orifices are perpendicularly impinged on the inner surface of a rectangular wind tunnel at a short distance between the orifice plate and impinged surface (H) of 2D, where D is a diameter of the orifice. The jet velocity was fixed corresponding to Re=13,400 for all experiments, and the cross-flow velocity was varied at three different velocity ratios (velocity ratio, jet velocity/cross-flow velocity) of 3, 5, and 7. The heat transfer characteristic was visualized using a thermochromic liquid crystal sheet, and the Nusselt number distribution was evaluated by an image processing technique. The flow pattern on the impinged surface was also visualized by an oil film technique. The numerical simulation was used to explore a flow interaction between the impinging jets and cross-flow. The results indicated that Nusselt number peak increased by the increasing cross-flow velocity for short jet-to-plate distance. For the range determined, the maximum local Nusselt number peak was obtained at VR=3 as the consequence of high velocity and high turbulence kinetic energy of jet impingement.