Herein we present a systematic investigation On the promotional effect of base in metal catalysed hydrogenolysis of lignin model compounds and organosolv lignin. The research started with the evaluation of pH effects (pH 1-14) on the hydrogenolysis of a lignin beta-O-4 model compound over a Ru catalyst (a stable catalyst over a wide pH range), from which a significantly increased selectivity towards monomeric compounds was observed in the presence of base. This promotional effect was studied in detail over bimetallic Ni7Au3 nanoparticles. Addition of a strong base such as NaOH significantly enhanced the activity and selectivity for C-O bond hythogenolysis over undesired hydrogenation reactions, not only in lignin model compounds but also in real lignin conversion. Notably, the yield for monomeric aromatic compounds from lignin over Ni7Au3 catalyst increased ca. 100% after adding NaOH as a promoter, under the same reaction conditions. Mechanistic study suggest that addition of base significantly reduced the benzene ring hydrogenation activity of the metal catalysts. The effect of adding different bases over various metal catalysts were also investigated. (C) 2014 Elsevier Ltd. All rights reserved,