Chemical Engineering & Technology, Vol.37, No.8, 1369-1375, 2014
Optimized Coating through Phase Separation in Tablets by Melt Crystallization
The coating process is a crucial step in conventional industrial tablet production. Here, a simpler method to coat the tablets is realized by melt crystallization technology. Phase separation of the mixture components, which need to be eutectic, is investigated for lauric acid and ibuprofen. Use of a colored complex of lauric acid, the expected phase separation was visualized. Post-production analyses confirmed the two different solidifying phases. Variation of certain parameters within the drop forming simulation experiment, to test their effects on the tablet geometry and phase separation, provided an important entry in the tablet coating formula. Cooling the crystallizing drops from the top and the bottom resulted in the generation of evenly coated tablets, a major goal in tablet production.