Bioenergy is one of the most significant energy resources with potential to serve as a partial replacement for fossil. As an agricultural state, Missouri has great potential to use biomass for energy production. In 2008, Missouri adopted a renewable portfolio standard (RPS) yet about 80% of its power supply still comes from coal. This paper describes a feasibility study of co-firing biomass in existing coal-powered plants in Missouri. Specifically, this study developed a linear programming model and simulated six scenarios to assess the economic feasibility and greenhouse gas impacts of co-firing biomass in existing qualified coal power plants in Missouri. The results of this study indicate that although co-firing can reduce the emissions of GHG and environmental pollutants, it is still not an economically feasible option for power generation without additional economic or policy incentives or regulations which could take environmental costs into account. Based on these results, strategies and policies to promote the utilization of biomass and to increase its competitiveness with fossil fuels are identified and discussed. (C) 2014 Elsevier Ltd. All rights reserved.