An altered ion homeostasis due to impaired membrane transporters is known to be involved in the pathophysiology of many chronic diseases. Resveratrol, a phytoalexin, has been reported to elicit pleiotropic health-promoting effects, however, the mechanism(s) which underlie these effects remain speculative. The present study investigate the modulatory role of resveratrol on erythrocyte membrane Ca(2+)ATPase (PMCA pump), Na+/K+-ATPase (MCA pump), and Na+/H+ exchanger (NHE) in control and experimental-oxidative stress conditions. Results suggest that resveratrol is a potent modulator of membrane transporters evidenced by stimulation of PMCA and NKA pumps and down-regulation of NHE. The observed effects on membrane transporters correlated with susceptibility of erythrocyte membrane to oxidative damage. The findings provide an insight into the role of membrane transporters and their involvement in the health beneficial effects of resveratrol. (C) 2014 Elsevier Inc. All rights reserved.