Ethanol modified supercritical carbon dioxide extraction of antioxidant rich extract from Pereskia bleo

K.M. Sharif; M.M. Rahman; J. Azmir; S.H. Shamsudin; M.S. Uddin; T.K. Fahim; I.S.M. Zaidul

Journal of Industrial and Engineering Chemistry, Vol.21, 1314-1322, January, 2015

DOI10.1016/j.jiec.2014.05.047 Export Citation

Ethanol modified supercritical carbon dioxide extraction of antioxidant rich extract from Pereskia bleo

K.M. Sharif¹, M.M. Rahman^{1, †}, J. Azmir¹, S.H. Shamsudin¹, M.S. Uddin^{1, 2}, T.K. Fahim¹, and I.S.M. Zaidul¹

¹Kulliyyah of Pharmacy, International Islamic University Malaysia, Jalan Sultan Ahmed Shah, 25200 Kuantan, Pahang, Malaysia
²Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6205, Bangladesh

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Supercritical fluid extraction (SFE) of Pereskia bleo leaves was carried out with systematic experimental study to screen and optimize the factors affecting yield and antioxidant activity. Initially, five factors were studied by Plackett-Burman study to screen the most influential factors. Consequently, three significantly affecting factors were optimized by Box-Behnken study. At the optimum condition (52 °C, 36MPa and 1.5% ethanol of total CO2) yield and IC50 value obtained by SFE were higher thanwater extract and lower than methanol extract. GC-MS analysis showed that the ethanol modified supercritical carbon dioxide has increased efficiency for extracting antioxidant compounds, α-tocopherol, β-sitosterol and erythritol.

Keywords:Supercritical fluid extraction;Antioxidant activity;Modifier

[References]

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McDougall GJ, Ross HA, Ikeji M, Stewart D, J. Agric. Food Chem., 56, 3016 (2008)
Zhang Y, Seeram NP, Lee R, Feng L, Heber D, J. Agric. Food Chem., 56, 670 (2008)
Smelcerovic A, Lepojevic Z, Djordjevic S, Chem. Eng. Technol., 27(12), 1327 (2004)
Azmir J, Zaidul ISM, Rahman MM, Sharif KM, Mohamed A, Sahena F, Jahurul MHA, Ghafoor K, Norulaini NAN, Omar AKM, J. Food Eng., 117(4), 426 (2013)
Lang Q, Wai CM, Talanta, 53, 771 (2001)
Reverchon E, De Marco I, J. Supercrit. Fluids, 38(2), 146 (2006)
Ibanez E, Herrero M, Mendiola JA, Castro-Puyana M, in: Hayes M (Ed.), Marine Bioactive Compounds, Springer, US, 2012.
Caldera G, Figueroa Y, Vargas M, Santos DT, Marquina-Chidsey G, Int. J. Food Eng., 8 (2012)
Majdi S, Barzegar M, Jabbari A, AghaAlikhani M, J. Agric. Sci. Technol., 14, 1053 (2012)
Sharif KM, Rahman MM, Azmir J, Mohamed A, Jahurul MHA, Sahena F, Zaidul ISM, J. Food Eng., 124, 105 (2014)
de Melo MMR, Silvestre AJD, Silva CM, J. Supercrit. Fluids, doi:http://dx.doi.org/10.1016/j.supflu.2014.04.007. (2014)
Ebada SS, Edrada RA, Lin W, Proksch P, Nat. Protoc., 3, 1820 (2008)
Heyden YV, Nijhuis A, Smeyers-Verbeke J, Vandeginste BGM, Massart DL, J. Pharm. Biomed. Anal., 24, 723 (2001)
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Tyssedal J, Niemi R, Norges Teknisk-Naturvitenskapelige Universitet Statistica 3 2011; 1
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Tabera J, Guinda A, Ruiz-Rodriguez A, Senorans FJ, Ibanez E, Albi T, Reglero G, J. Agric. Food Chem., 52, 4774 (2004)
Casas L, Mantell C, Rodriguez M, Torres A, Macias FA, de la Ossa EM, J. Supercrit. Fluids, 41(1), 43 (2007)
Lompart M, Lorenzo R, Cela R, J. Chromatogr. Sci., 34, 43 (1996)
Khajeh M, J. Supercrit. Fluids, 55(3), 944 (2011)
Khajeh M, Nat. Prod. Res., 26, 1926 (2012)
Herrero M, Cifuentes A, Ibanez E, Food Chem., 98, 136 (2006)
Leitao NCMCS, Prado GHC, Veggi PC, Meireles MAA, Pereira CG, J. Supercrit. Fluids, 78, 114 (2013)
Kassama LS, Shi J, Mittal GS, Sep. Purif. Technol., 60(3), 278 (2008)
Wang L, Yang B, Du X, Yi C, Food Chem., 108, 737 (2008)
Moura PM, Prado GHC, Meireles MAA, Pereira CG, J. Supercrit. Fluids, 62, 116 (2012)
Farias-Campomanes AM, Rostagno MA, Meireles MAA, J. Supercrit. Fluids, 77, 70 (2013)
Casas L, Mantell C, Rodriguez M, de la Ossa EJM, Roldan A, De Ory I, Caro I, Blandino A, J. Food Eng., 96(2), 304 (2010)
Vayalil PK, Crit. Rev. Food Sci. Nutr., 52, 249 (2012)
Pejin B, Savic A, Sokovic M, Glamoclija J, Ciric A, Nikolic M, Radotica K, Mojovic M, Nat. Prod. Res., 28 (2014)
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Baliga MS, Baliga BRV, Kandathil SM, Bhat HP, Vayalil PK, Food Res. Int., 44, 1812 (2011)
Osman R, J. Chem. (2013)
Gao Y, Zhu L, Chemosphere, 55, 1169 (2004)
Rodriguez-Meizoso I, Jaime L, Santoyo S, Senorans FJ, Cifuentes A, Ibanez E, J. Pharm. Biomed. Anal., 51, 456 (2010)

[Referenced By]

[1] Sharif KM, Rahman MM, Zaidul ISM, Azmir J, Akanda MJH, Mohamed A, Shamsudin SH, Res. J. Biotechnol., 8, 134 (2013)

[2] McDougall GJ, Ross HA, Ikeji M, Stewart D, J. Agric. Food Chem., 56, 3016 (2008)

[3] Zhang Y, Seeram NP, Lee R, Feng L, Heber D, J. Agric. Food Chem., 56, 670 (2008)

[4] Smelcerovic A, Lepojevic Z, Djordjevic S, Chem. Eng. Technol., 27(12), 1327 (2004)

[5] Azmir J, Zaidul ISM, Rahman MM, Sharif KM, Mohamed A, Sahena F, Jahurul MHA, Ghafoor K, Norulaini NAN, Omar AKM, J. Food Eng., 117(4), 426 (2013)

[6] Lang Q, Wai CM, Talanta, 53, 771 (2001)

[7] Reverchon E, De Marco I, J. Supercrit. Fluids, 38(2), 146 (2006)

[8] Ibanez E, Herrero M, Mendiola JA, Castro-Puyana M, in: Hayes M (Ed.), Marine Bioactive Compounds, Springer, US, 2012.

[9] Caldera G, Figueroa Y, Vargas M, Santos DT, Marquina-Chidsey G, Int. J. Food Eng., 8 (2012)

[10] Majdi S, Barzegar M, Jabbari A, AghaAlikhani M, J. Agric. Sci. Technol., 14, 1053 (2012)

[11] Sharif KM, Rahman MM, Azmir J, Mohamed A, Jahurul MHA, Sahena F, Zaidul ISM, J. Food Eng., 124, 105 (2014)

[12] de Melo MMR, Silvestre AJD, Silva CM, J. Supercrit. Fluids, doi:http://dx.doi.org/10.1016/j.supflu.2014.04.007. (2014)

[13] Ebada SS, Edrada RA, Lin W, Proksch P, Nat. Protoc., 3, 1820 (2008)

[14] Heyden YV, Nijhuis A, Smeyers-Verbeke J, Vandeginste BGM, Massart DL, J. Pharm. Biomed. Anal., 24, 723 (2001)

[15] Zhao BS, Fu YJ, Wang W, Zu YG, Gu CB, Luo M, Efferth T, Innov. Food Sci. Emerg. Technol., 12, 577 (2011)

[16] Tyssedal J, Niemi R, Norges Teknisk-Naturvitenskapelige Universitet Statistica 3 2011; 1

[17] Robinson AR, Gheneim R, Kozak RA, J. Exp. Bot., 56, 2807 (2005)

[18] Tabera J, Guinda A, Ruiz-Rodriguez A, Senorans FJ, Ibanez E, Albi T, Reglero G, J. Agric. Food Chem., 52, 4774 (2004)

[19] Casas L, Mantell C, Rodriguez M, Torres A, Macias FA, de la Ossa EM, J. Supercrit. Fluids, 41(1), 43 (2007)

[20] Lompart M, Lorenzo R, Cela R, J. Chromatogr. Sci., 34, 43 (1996)

[21] Khajeh M, J. Supercrit. Fluids, 55(3), 944 (2011)

[22] Khajeh M, Nat. Prod. Res., 26, 1926 (2012)

[23] Herrero M, Cifuentes A, Ibanez E, Food Chem., 98, 136 (2006)

[24] Leitao NCMCS, Prado GHC, Veggi PC, Meireles MAA, Pereira CG, J. Supercrit. Fluids, 78, 114 (2013)

[25] Kassama LS, Shi J, Mittal GS, Sep. Purif. Technol., 60(3), 278 (2008)

[26] Wang L, Yang B, Du X, Yi C, Food Chem., 108, 737 (2008)

[27] Moura PM, Prado GHC, Meireles MAA, Pereira CG, J. Supercrit. Fluids, 62, 116 (2012)

[28] Farias-Campomanes AM, Rostagno MA, Meireles MAA, J. Supercrit. Fluids, 77, 70 (2013)

[29] Casas L, Mantell C, Rodriguez M, de la Ossa EJM, Roldan A, De Ory I, Caro I, Blandino A, J. Food Eng., 96(2), 304 (2010)

[30] Vayalil PK, Crit. Rev. Food Sci. Nutr., 52, 249 (2012)

[31] Pejin B, Savic A, Sokovic M, Glamoclija J, Ciric A, Nikolic M, Radotica K, Mojovic M, Nat. Prod. Res., 28 (2014)

[32] Liolios CC, Sotiroudis GT, Chinou I, Nutrition, 64, 52 (2009)

[33] Baliga MS, Baliga BRV, Kandathil SM, Bhat HP, Vayalil PK, Food Res. Int., 44, 1812 (2011)

[34] Osman R, J. Chem. (2013)

[35] Gao Y, Zhu L, Chemosphere, 55, 1169 (2004)

[36] Rodriguez-Meizoso I, Jaime L, Santoyo S, Senorans FJ, Cifuentes A, Ibanez E, J. Pharm. Biomed. Anal., 51, 456 (2010)