Hydrodynamic focusing for micro-rheological single-particle study

Marek Dziubiński

Korea-Australia Rheology Journal, Vol.27, No.1, 11-15, February, 2015

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Hydrodynamic focusing for micro-rheological single-particle study

Marek Dziubiński^†

Department of Chemical Engineering, Lodz University of Technology, Wolczańska 213, 90-924 Lodz, Poland

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Hydrodynamic focusing is a widely used tool in microfluidics world. Typical working models are treating this phenomenon as two-dimensional, however the requirements of high throughput analysis show the urgent need to operate in higher Reynolds number range Re > 10, where the three dimensional effects are no longer negligible. Current work, based on both experimental results of confocal laser scanning microscopy (CLSM) and computational fluid dynamics (CFD) modeling describes the problematic range of flow parameters and presents the model describing the shape of the focused stream. In specific, the discussion is aimed at possible use of the proposed solution in single particle rheology, where such a model gives novel control possibilities over the experimental parameters.

Keywords:hydrodynamic focusing;micro-rheology;single particle;focused stream

[References]

Blonski S, Domagalski P, Dziubinski M, Kowalewski TA, Arch. Mech., 63, 163 (2011)
Boyd DA, Shields AR, Howell PB, Ligler FS, Lab Chip, 13, 3105 (2013)
Domagalski PM, Mielnik MM, Lunde I, Saetran LR, Heat Transfer Eng., 28, 680 (2008)
Domagalski P, Dziubinski M, Przem. Chem., 89(7), 949 (2010)
Faivre M, Abkarian M, Bickraj K, Stone HA, Biorheology, 43, 147 (2006)
Garstecki P, Gitlin I, DiLuzio W, Whitesides GM, Kumacheva E, Stone HA, Appl. Phys. Lett., 85, 2649 (2004)
Ivorra B, Redondo JL, Santiago JG, Ortigosa PM, Ramos AM, Phys. Fluids, 25, 032001 (2013)
Jung H, Chun MS, Chang MS, Sorting of human mesenchymal stem cells by applying optimally designed microfluidic chip filtration, Analyst, DOI: 10.1039/c4an01430h. (2015)
Knight JB, Vishwanath A, Brody JP, Austin RH, Phys. Rev. Lett., 80, 3863 (1998)
Kunstmann-Olsen C, Hoyland JD, Rubahn HG, Microfluid. Nanofluid., 12, 795 (2012)
Mao X, Lin SCS, Dong C, Huang TJ, Lab Chip, 9, 1583 (2009)
Nasir M, Price DT, Shriver-Lake LC, Ligler F, Lab Chip, 10, 2787 (2010)
Nasir M, Mott DR, Kennedy MJ, Golden JP, Ligler FS, Microfluid. Nanofluid., 11, 119 (2011)
Rodriguez-Trujillo R, Mills CA, Samitier J, Gomila G, Microfluid. Nanofluid., 3, 171 (2007)
Rohsenow WM, Hartnett JP, Cho YI, Handbook of Heat Transfer, 3rd Ed., McGraw-Hill, New York. (1998)
Sethu P, Anahtar M, Moldawer LL, Tompkins RG, Toner M, Anal. Chem., 76, 6247 (2004)
Solli LA, Saetran LR, Mielnik MM, Numerical Modeling of Fluid Layers in Hydrodynamic Focusing, Proceedings of Second International Conference on Transport Phenomena in Micro and Nanodevices, Barga, Italy. (2006)
Wang F, Wang H, Wang J, Wang HY, Rummel PL, Garimella SV, Lu C, Biotechnol. Bioeng., 100(1), 150 (2008)
Wong PK, Lee YK, Ho CM, J. Fluid Mech., 497, 55 (2003)

[Referenced By]

[1] Blonski S, Domagalski P, Dziubinski M, Kowalewski TA, Arch. Mech., 63, 163 (2011)

[2] Boyd DA, Shields AR, Howell PB, Ligler FS, Lab Chip, 13, 3105 (2013)

[3] Domagalski PM, Mielnik MM, Lunde I, Saetran LR, Heat Transfer Eng., 28, 680 (2008)

[4] Domagalski P, Dziubinski M, Przem. Chem., 89(7), 949 (2010)

[5] Faivre M, Abkarian M, Bickraj K, Stone HA, Biorheology, 43, 147 (2006)

[6] Garstecki P, Gitlin I, DiLuzio W, Whitesides GM, Kumacheva E, Stone HA, Appl. Phys. Lett., 85, 2649 (2004)

[7] Ivorra B, Redondo JL, Santiago JG, Ortigosa PM, Ramos AM, Phys. Fluids, 25, 032001 (2013)

[8] Jung H, Chun MS, Chang MS, Sorting of human mesenchymal stem cells by applying optimally designed microfluidic chip filtration, Analyst, DOI: 10.1039/c4an01430h. (2015)

[9] Knight JB, Vishwanath A, Brody JP, Austin RH, Phys. Rev. Lett., 80, 3863 (1998)

[10] Kunstmann-Olsen C, Hoyland JD, Rubahn HG, Microfluid. Nanofluid., 12, 795 (2012)

[11] Mao X, Lin SCS, Dong C, Huang TJ, Lab Chip, 9, 1583 (2009)

[12] Nasir M, Price DT, Shriver-Lake LC, Ligler F, Lab Chip, 10, 2787 (2010)

[13] Nasir M, Mott DR, Kennedy MJ, Golden JP, Ligler FS, Microfluid. Nanofluid., 11, 119 (2011)

[14] Rodriguez-Trujillo R, Mills CA, Samitier J, Gomila G, Microfluid. Nanofluid., 3, 171 (2007)

[15] Rohsenow WM, Hartnett JP, Cho YI, Handbook of Heat Transfer, 3rd Ed., McGraw-Hill, New York. (1998)

[16] Sethu P, Anahtar M, Moldawer LL, Tompkins RG, Toner M, Anal. Chem., 76, 6247 (2004)

[17] Solli LA, Saetran LR, Mielnik MM, Numerical Modeling of Fluid Layers in Hydrodynamic Focusing, Proceedings of Second International Conference on Transport Phenomena in Micro and Nanodevices, Barga, Italy. (2006)

[18] Wang F, Wang H, Wang J, Wang HY, Rummel PL, Garimella SV, Lu C, Biotechnol. Bioeng., 100(1), 150 (2008)

[19] Wong PK, Lee YK, Ho CM, J. Fluid Mech., 497, 55 (2003)