화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Polymer(Korea), Vol.39, No.1, 40-45, January, 2015
Export Citation
비용매 휘발법을 이용한 생체모사 혈액친화성 폴리락티드-카프로락톤 공중합체 필름의 제조
Blood-compatible Bio-inspired Surface of Poly(L-lactide-co-ε-caprolactone) Films Prepared Using Poor Co-solvent Casting
임진익1, 김수현2, 3, †
  • 1단국대학교 화학공학과
  • 2한국과학기술연구원 생체재료연구단
  • 3고려대학교 KU-KIST 대학원
Jin Ik Lim1, and Soo Hyun Kim2, 3, †
  • 1Laboratory of Biointerfaces/Tissue Engineering, Department of Chemical Engineering, Institute of Tissue Regeneration Engineering, College of Engineering, Dankook University, Jukjeon-dong, Yongin-si, Gyeonggi-do 448-701, Korea
  • 2Division of Life and Health Sciences, Biomaterials Research Center, Korea Institute of Science and Technology, Seoul 136-791, Korea
  • 3KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 136-701, Korea
E-mail:
초록
혈항혈전성 표면의 제조를 위해 간단한 비용매 휘발 방법을 통하여 고탄성체이면서 생분해성 폴리 락티드-카프로락톤 공중합체 필름의 표면상에 연잎 구조물과 유사한 마이크로 돌기를 만들어 주었다. 표면 구조와 소수성도, 항혈전 효과 등을 시험했으며, 결정화도와 탄성회복률 등의 물리적 특성도 분석하였다. 그 결과 비용매와 메틸렌클로라이드의 혼합 부피비 1:2에서 연잎표면과 유사한 최적의 효과를 얻었으며, 이때 수접촉각은 124o였다. 혈소판 부착시험에서는 처리하지 않는 군에 비해 약 10%만 부착되는 효과를 확인할 수 있었다.
Simple poor-cosolvent casting was used to surface treat biodegradable elastic poly(L-lactide-co-ε-caprolactone) (PLCL; 50:50) copolymer films that presented lotus-leaf-like structures. We evaluated whether the lotus-leaflike-structured PLCL (L-PLCL) films could be used as a biomaterial for artificial vascular grafts. The surface morphology, hydrophobicity, and antithrombotic efficiency of the films were examined while immersed in platelet-rich plasma (PRP) using scanning electron microscopy (SEM) and a contact angle meter. The recovery and crystallinity of the films were measured using a tensile-strength testing machine and an X-ray diffractometer, respectively. The solvent containing acetic acid, as a poor co-solvent, and methylene chloride mixed in a 1:2 ratio produced an optimal PLCL film with a water contact angle of approximately 124o. Furthermore, the surface of the L-PLCL films immersed in PRP showed a lower rate of platelet adhesion (<10%) than that of the surface of an untreated PLCL film immersed in PRP.
Keywords:antithrombotic material;lotus-leaf-like structure;co-solvent system;blood vessel;surface modification.
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