In this study, the solution and self aggregation properties of sodium dodecyl sulfate (SDS) in presence of synthesized small molecules i.e. 3-(2-chloro benzylideneamine))-2-(furan-2-yl) quinazoline-4(3H) one (Q1) and N-(2-(p-tolyl carbamoyl) phenyl) furan-2-carboxamide (Q2) has been determined. The two compounds were earlier screened for anticancer activity from NCI, USA. In order to investigate the physico-chemical properties, simple and controlled methods were employed to obtain critical micellar concentration (CMC) values and thermo-acoustic parameters via conductance, compressibility coefficient (beta), apparent molar volume (phi(v)) and apparent molar adiabatic compressibility (phi(k)) of SDS in the presence of Q1/Q2 at different temperatures (25, 30, and 35 degrees C). In addition, the effect of the addition of Q1/Q2 in SOS solution and to gain information regarding interaction between the molecules, FTIR and H-1 NMR spectroscopic analysis was also carried out. The presence of different substitutions on the molecules affecting SDS behavior has also been discussed. (C) 2013 Elsevier B.V. All rights reserved.