Ni-Cu catalysts derived from hydrotalcite-like compounds were prepared and evaluated in aqueous-phase reforming of glycerol. The catalysts were characterized by chemical composition, textural analysis, crystalline structure and reducibility. The reaction was carried out in a batch reactor with solution of 10 wt.% glycerol, at 250 and 270 degrees C. A maximum glycerol conversion of 60% was achieved at 270 degrees C. In the gas phase, the H-2 selectivity was always higher than 80% and formation of CO was very low (<3%) at 250 degrees C. The addition of Cu decreased the formation of methane. H-2 is consumed during the reaction at 270 degrees C, mainly for Cu-containing catalysts, with simultaneous formation of propylene glycol in the liquid phase. Acetol, lactic acid and acetaldehyde were also formed in the liquid phase, at both temperatures. (C) 2012 Elsevier Ltd. All rights reserved.