The degradation of reactive brilliant red K-2BP (K-2BP) in aqueous solution using swirling jet-induce cavitation (SJC) combined with Fenton process was studied and an evident synergistic effect was observed. The effects of various operating parameters such as H2O2 and Fe2+ dosage, fluid pressure, pH value and temperature of the solution on the degradation of K-2BP have been investigated. The removal of K-2BP in aqueous solution was increased with increasing of H2O2 and Fe2+ addition. But excess Fe2+ has a negative effect on the removal of K-2BP. It was also found that lower pH, higher temperature, and higher pressure of fluid are favorable for the degradation of K-2BP. The degradation mechanism of K-2BP was also discussed with the change of UV-Vis spectra of K-2BP at different degradation time. (C) 2014 Elsevier B.V. All rights reserved.