Electrodialysis (ED) is a separation technique in which an electrical field is used to transport anions and cations through ion conductive membranes positioned between two adjacent compartments, often in view of desalination. ED forces ions to move from a low concentration compartment (diluate) to a high concentration compartment (concentrate). A co-current hydraulic flow mode of the salt solutions through the ED stack compartments is often applied. Under such conditions and considering the practical dimensions of industrial ED stacks, a series of stacks is mostly required in order to obtain a specified level of desalination in the diluate. A co-current hydraulic flow mode is common practice in ED but the approach can result in a high concentration difference between concentrate and diluate in the final stacks, which is disadvantageous. In this paper, the theoretical and practical implications of changing the classic co-current hydraulic flow mode into a mixed flow mode are studied. In such a mixed flow mode the internal hydraulic flow of diluate and concentrate is co-current in the stack compartments but is externally counter-current over the total series of stacks. The mixed flow mode favors a much lower concentrate and diluate concentration difference within each stack when compared to the full co-current mode. Additional advantages by introducing the feed&bleed principle in the concept are demonstrated too. (C) 2012 Elsevier B.V. All rights reserved.