In this work, the particle-gas flows in two small sampling cyclone separators are simulated by means of Large Eddy Simulations (LES). The Eulerian-Lagrangian approach is used to calculate the fluid flow along with the particle motion. Unlike Reynolds-averaged turbulence models (RANS), LES modeling is advantageous as it does not demand turbulence dispersion models for the particles, which in turn requires parameter tuning that may not be applicable to arbitrary cyclone geometries and operating conditions. The results of three integration schemes for the particle motion equations and two collection criteria are shown and discussed. The grade efficiencies computed are compared with the experimental ones and shown to be sensitive to Reynolds numbers and geometry variations. It can be concluded that, besides the independence of ad hoc parameters, LES offers a robust, reliable modeling option for such flows. (C) 2012 Elsevier B.V. All rights reserved.