In Vitro Degradation and Controlled Drug Release Behavior of the Microgels based on Poly(caprolactone diol)

Kong Soo Kim; Neil. B. Graham

Journal of Industrial and Engineering Chemistry, Vol.4, No.3, 221-225, September, 1998

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In Vitro Degradation and Controlled Drug Release Behavior of the Microgels based on Poly(caprolactone diol)

Kong Soo Kim^†, and Neil. B. Graham¹

Dept. of Chemical Engineering, Chungbuk University, Cheongju 361-763, Korea
¹Dept. of Pure & Applied Chemistry, University of Stathclyde, 295, Cathedral Street, Glasgow, G1 1XL, Scotland, U. K., UK

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The microgels derived from poly(caprolactone diol) (PCD), 1,2,6-hexane triol (HT) and 3,4-dihydro-2H-pyranyl-2-methyl-(3,4-dihydro-2H-pyran-2-carboxylate) (C1) have been used as novel and promising matrices for controlled drug delivery system. They were evaluated the biodegradation behavior and morphology on the asymmetric degradation of the microgel films. These microgels were degraded in acidic, alkaline and enzymatic solution of esterase and the degradation is due to hydrolitic and enzymatic degradation of the ester linkage of the microgels. For microgels with a higher crosslinking degrees, the release time was considered longer and the comparative release rate were in the order of MG-1>MG-2>MG-3. It is indicated that an increase in the crosslinking density retards due to a decrease in permeability of the network and a decrease in the rate cleavage of ester linkage of the microgels by the enzymatic degradation.

Keywords:microgels;enzymatic degradation;controlled drug release;biodegradable polymers

[References]

Cook WJ, Cameron JA, Bell JP, Huang SJ, J. Polym. Sci. C: Polym. Lett., 19, 159 (1981)
Jayabalan M, Kumar NS, Rathina K, Kumari TV, J. Biomed. Mater. Res., 25, 1431 (1991)
Gurav N, Downes S, J. Mater. Sci.: Mater. Med., 5, 784 (1994)
Schop AD, Wise DL, Sell KW, Dressler DP, Skornick WA, J. Biomed. Mater. Res., 11, 489 (1977)
Andriano KP, Daniels AV, Heller J, J. Appl. Biomater., 3, 197 (1992)
Kinoshita Y, Kirigakuho M, Kobayashi M, Tabata T, Shimura K, Ikada Y, Biomaterials, 14, 729 (1993)
Graham NB, Brit. Polym. J., 10, 260 (1978)
Heller J, Biomaterials, 1, 51 (1980)
Pitt CG, Hendren RW, Schindler A, Woodward SC, J. Control. Release, 1, 3 (1984)
Lenaets V, Dumoulin Y, Mateescu MA, J. Control. Release, 15, 39 (1991)
Sanders LM, McRae GI, Vitale KM, Kell BA, J. Control. Release, 2, 187 (1985)
Floy BJ, Visor GC, Sanders LM, Polymeric Delivery Systems, M.A. El-Nokaly, D.M. Piatt, and B.A. Charpentier (ed.), Am. Chem. Soc., Washington D.C., pp. 154-167 (1993)
Benedict CB, Huang SJ, J. Appl. Polym. Sci., 28, 335 (1983)
Benedict CV, Cook WJ, Jarrett P, Cameron JA, Huang SJ, Bell JP, J. Appl. Polym. Sci., 28, 327 (1983)
Pitt CG, Schindler A, Biodegradables and Delivery Systems for Coatracepton, Hafez and W.A. van Os (ed.), Hall Medical Publisher, Boston, p. 17 (1980)
Mochizuki M, Hirano M, Kanmuri Y, Kudo K, Tokiwa Y, J. Appl. Polym. Sci., 55, 289 (1955)
Cohen S, Yoshioka T, Lucarelli M, Hwang LH, Langer R, Pharm. Res., 8, 713 (1991)
Kabanov AV, Batracova EV, Melik-Nubarov NS, Fedoseev NA, Dorodnich YY, J. Control. Release, 22, 141 (1992)
Couvreur P, Vauthier C, J. Control. Release, 17, 187 (1991)
McNeil ME, Graham NB, J. Biomater. Sci.-Polym. Ed., 5, 111 (1993)
Graham NB, Mao J, Urquhart A, Makromol. Chem., 240, 113 (1996)
Graham NB, Kim KS, Korea Polym. J., submitted (1997)
Graham NB, Zulfugar M, McDonald BB, J. Control. Release, 5, 243 (1988)
Gandler B, Gurny R, Dodlker E, J. Control. Release, 5, 272 (1988)
Sanders IM, Kent JS, McRae GI, Vickery BH, Tice TR, Lewis DH, J. Pharm. Sci., 73, 1294 (1990)

[Referenced By]

[1] Cook WJ, Cameron JA, Bell JP, Huang SJ, J. Polym. Sci. C: Polym. Lett., 19, 159 (1981)

[2] Jayabalan M, Kumar NS, Rathina K, Kumari TV, J. Biomed. Mater. Res., 25, 1431 (1991)

[3] Gurav N, Downes S, J. Mater. Sci.: Mater. Med., 5, 784 (1994)

[4] Schop AD, Wise DL, Sell KW, Dressler DP, Skornick WA, J. Biomed. Mater. Res., 11, 489 (1977)

[5] Andriano KP, Daniels AV, Heller J, J. Appl. Biomater., 3, 197 (1992)

[6] Kinoshita Y, Kirigakuho M, Kobayashi M, Tabata T, Shimura K, Ikada Y, Biomaterials, 14, 729 (1993)

[7] Graham NB, Brit. Polym. J., 10, 260 (1978)

[8] Heller J, Biomaterials, 1, 51 (1980)

[9] Pitt CG, Hendren RW, Schindler A, Woodward SC, J. Control. Release, 1, 3 (1984)

[10] Lenaets V, Dumoulin Y, Mateescu MA, J. Control. Release, 15, 39 (1991)

[11] Sanders LM, McRae GI, Vitale KM, Kell BA, J. Control. Release, 2, 187 (1985)

[12] Floy BJ, Visor GC, Sanders LM, Polymeric Delivery Systems, M.A. El-Nokaly, D.M. Piatt, and B.A. Charpentier (ed.), Am. Chem. Soc., Washington D.C., pp. 154-167 (1993)

[13] Benedict CB, Huang SJ, J. Appl. Polym. Sci., 28, 335 (1983)

[14] Benedict CV, Cook WJ, Jarrett P, Cameron JA, Huang SJ, Bell JP, J. Appl. Polym. Sci., 28, 327 (1983)

[15] Pitt CG, Schindler A, Biodegradables and Delivery Systems for Coatracepton, Hafez and W.A. van Os (ed.), Hall Medical Publisher, Boston, p. 17 (1980)

[16] Mochizuki M, Hirano M, Kanmuri Y, Kudo K, Tokiwa Y, J. Appl. Polym. Sci., 55, 289 (1955)

[17] Cohen S, Yoshioka T, Lucarelli M, Hwang LH, Langer R, Pharm. Res., 8, 713 (1991)

[18] Kabanov AV, Batracova EV, Melik-Nubarov NS, Fedoseev NA, Dorodnich YY, J. Control. Release, 22, 141 (1992)

[19] Couvreur P, Vauthier C, J. Control. Release, 17, 187 (1991)

[20] McNeil ME, Graham NB, J. Biomater. Sci.-Polym. Ed., 5, 111 (1993)

[21] Graham NB, Mao J, Urquhart A, Makromol. Chem., 240, 113 (1996)

[22] Graham NB, Kim KS, Korea Polym. J., submitted (1997)

[23] Graham NB, Zulfugar M, McDonald BB, J. Control. Release, 5, 243 (1988)

[24] Gandler B, Gurny R, Dodlker E, J. Control. Release, 5, 272 (1988)

[25] Sanders IM, Kent JS, McRae GI, Vickery BH, Tice TR, Lewis DH, J. Pharm. Sci., 73, 1294 (1990)