Flow behavior of particles is simulated by means of two-fluid model combining with kinetic theory of granular flow in an inverse liquid-solid fluidized bed. The Huilin-Gidaspow drag model is used to obtain the interphase interaction of liquid and solid phases. The virtual mass force is considered in simulations. A detailed description of the model equations used has been presented. Predictions are compared with experimental data measured by Renganathan (2005) in an inverse liquid-solid fluidized bed. This comparison shows that the present model can capture flow behavior of liquid and solids phases in an inverse fluidized bed. The distributions of velocity and volume fraction are predicted at the different superficial liquid velocities. Simulations indicate that axial velocities of particles and the bed expansion height are increased with an increase of liquid velocity. The granular temperature as a function of solids concentrations is computed from simulations. Roughly, the granular temperatures increase, reach maximum, and then decrease with the increase of solids volume fraction. The effects of liquid viscosity and temperature on flow behavior of particles are generally scarce using CFD. Present simulations show the temperature is not main effect on flow of particles in an inverse liquid-solid fluidized bed. The bed height and velocity increase with the increase of fluid viscosity which effects on flow behavior of particles in the bed. (C) 2014 Elsevier B.V. All rights reserved.