The mixing and flow of granular materials in a conical tote blender are investigated using a GPU-based DEM software to explore new approaches to enhance mixing. The structure and dimensions of the blender and other simulation conditions are set according to experimental data from literature. A parametric study on fill level and rotation rate is carried out from which optimum values are found with respect to mixing rate, productivity and energy consumption. It is also found that the standard horizontal installation of the blender results in poor axial mixing, while inclining the blender at a certain angle can enhance mixing effectively. This may be ascribed to the larger mean particles velocity and better velocity distribution under such conditions, which is confirmed to be a consistent character for relatively large-scale systems. Furthermore, the effect of operating conditions for the inclined blender is also examined. It is close to those for the standard blender but has less effect on mixing rate. Crown Copyright (C) 2013 Published by Elsevier B.V. All rights reserved.