Pellets obtained from extrusion/spheronization generally do not disintegrate, especially those prepared from microcrystalline cellulose (MCC). The aim of present study was to develop fast disintegrating MCC pellets in order to improve drug dissolution. Formulations containing a model drug having a low aqueous solubility (i.e., indomethacin) and MCC were prepared with or without the addition of polyethylene glycol 400 (PEG 400; 0-10% w/w), polysorbate 80 (0-10% w/w) and croscarmellose sodium (CCS; 0-10% w/w) using a basket extruder and spheronizer. Ethanolic solution (15% v/v) was used as a granulating liquid. All formulations of pellets showed acceptable yield, aspect ratio and mechanical strength. The MCC pellets did not disintegrate and showed slow drug dissolution while the formulations with PEG 400 and/or polysorbate 80 disintegrated within 90 s and their drug dissolution was increased. The incorporation of CCS allowed the pellets to explode and disintegrate into two smaller pieces within 5 s after contact to an aqueous medium. The increased amount of CCS (from 2 to 10% w/w) insignificantly decreased disintegration time or increased drug dissolution. A slight difference in drug dissolution between freshly prepared pellets and pellets stored for 18 months may be due to the instability of drug in liquisolid environment. The results from this study suggest that the disintegrating or exploding MCC pellets could be prepared by incorporating PEG 400, polysorbate 80 and CCS, and promising for increasing dissolution of poorly water-soluble drugs. (C) 2012 Elsevier B.V. All rights reserved.