The random copolymers of epsilon-caprolactone (CL) and 2,2-ethylenedioxy propane-1,3-diol carbonate (EOPDC) were synthesized in bulk at 120 A degrees C using Sn(Oct)(2) as a catalyst. The poly(EOPDC-co-CL)s obtained were characterized by FT IR, H-1 NMR, C-13 NMR, GPC and DSC. The copolymers were obtained with yield of 84.2-97.8 %. The number-average molecular weight of the copolymer is 2.75-7.76 x 10(4) with a polydispersity of 1.52-1.68. The properties of the copolymer including the enzymatic degradation by Pseudomonas Cepacia lipase and drug-controlled release property were also investigated. The results showed that the copolymers are degradable at physiological conditions, and their degradation rate and release of Tegafur in the copolymers increase with increasing CL content in the copolymers.