Being subjected to the bending load, the structure of plate often has the high demand of bending rigidity. Fiber reinforced composites are used in an increasing number of structural applications, this due to their higher specific strength and specific stiffness compared to homogenous structural materials. For the orthotropic carbon fiber reinforced plastics (CFRP) plate with multiple holes, the application of the classical stress-strain analysis is very difficult because of the anisotropism and the effect of the holes. Therefore, the finite element method (FEM) is used to investigate the effect of a plate with multiple holes on the bending rigidity. The bending rigidity in the situation that stiffeners are fixed firmly to the plate is much higher than they are separated. The computation results are consistent to the experiment results. Based on the computation, a FEM model to optimize the bending rigidity of this kind of laminate circular plate with multiple holes is established. The placement of holes, the form and number of stiffeners are optimized in this paper. The computation results show if the number of stiffeners change to 6 and are matched with holes the bending rigidity will be increased remarkably and the weight of plate is reduced simultaneously. The computation results are consistent to the experiment results. The resolution of this study provides a reference for the design of this kind of laminate circular plate with multiple holes.