The aim of the present work is to synthesize amphiphilic copolymers with controlled properties, for example hydrophilicity and biodegradability. This kind of materials has many applications, like controlled drug delivery systems or biodegradable implants. In this work, synthesis and biodegradation of poly(2-hydroxyethyl methacrylate)-graft-poly(L-lactide) have been studied. The linear graft copolymer was synthesized using the macromonomer technique. The biodegradation was studied in an enzymatic environment, using the Proteinase K enzyme. The influence of different parameters (the nature of the substrate, the ratio between hydrophilic and hydrophobic components) on the degradation rate was investigated.