A new conductive superparamagnetic nanocomposite, gamma-Fe2O3/polyaniline-lonidamine (gamma-Fe2O3/PANI-LND), was synthesized successfully by two-step doping method. The properties of gamma-Fe2O3/PANI-LND were tested by FT-IR, X-ray diffractometry (XRD), X-ray photoelectron spectroscopy (XPS), vibrating sample magnetometer (VSM), transmission electron microscopy (TEM), thermogravimetric analysis (TGA) and cyclic voltammetry (CV). The results show that the particle size of gamma-Fe2O3/PANI-LND with stable electric conductivity and high electrochemical activity was approximately 40 nm, and the optimal molar ratio of n(LND) : n(gamma-Fe2)O(3/PANI) was 1:1 for the synthesis of gamma-Fe2O3/PANI-LND. The gamma-Fe2O3/PANI-LND could be concentrated in a magnetic field and located to the region of interest, which meant to potentially provide effective treatment of tumor cells with less therapeutic doses and side-effects. (C) 2014 Elsevier B.V. All rights reserved.