The excess second virial coefficient for (1,1,1,2-tetrafluoroethane + propane) has been measured at temperatures of 299.5K, 313.15K, 328.15K, and 343.15K, using the pressure-change-on-mixing method. The excess enthalpy and unlike-interaction second virial coefficients are also reported. The results have been correlated using the Tsonopoulos equation for virial coefficients.