Solubility of solute in supercritical fluids at different pressures and temperatures is one of the most important parameters necessary for design of any supercritical fluid-based processes. Among different supercritical fluids, carbon dioxide is one of the most widely used solvents due to its useful and green characteristics. In this work, with the assist of supercritical carbon dioxide as the solvent, solubility of cyproheptadine in different temperatures (308-338 K) and pressures (160-400 bar) are measured using static method. The obtained results demonstrated that solubility of cyproheptadine ranged between 3.35 x 10(-5) and 3.09 x 10(-3) based on mole fraction. A closer examination of measured solubility data show that not only solubility of cyproheptadine increases by increasing pressure but also experiences a cross over pressure about 200 bar. At last, the measured solubility data are correlated using four widely used density based correlations namely Mendez Santiago-Teja (MST), Kumar and Johnston (KJ), Bartle et al., and Chrastil models. The obtained results demonstrated that the best correlative capability was observed for Ki model leads to the average absolute relative deviation percent (AARD %) of 6.3%. (C) 2013 Elsevier B.V. All rights reserved.