Journal of Supercritical Fluids, Vol.61, 115-118, 2012
The Meerwein-Ponndorf-Verley type reaction in a mixture of supercritical isopropanol/CO2 in a continuous flow reactor in the presence of alumina
A system for efficient reduction of aromatic and aliphatic aldehydes to respective alcohols by the Meerwein-Ponndorf-Verley reaction at a contact time of less than 4 min and temperature below 473 K has been developed. The system comprises a continuous flow reactor, mixed supercritical isopropanol/CO2 solvent and alumina as a catalyst. Reduction of p-nitobenzealdehyde at 425 K yields p-nitrobenzyl alcohol; at 465 K the main reaction product is p-toluidine. alpha,beta-Unsaturated monoterpenic aldehyde myrtenal was reduced into corresponding alpha,beta-unsaturated alcohol myrtenol. At higher temperatures, reduction of myrtenol to saturated alcohol myrtanol becomes possible. (C) 2011 Elsevier B.V. All rights reserved.
Keywords:Meerwein-Ponndorf-Verley reduction;Supercritical isopropanol;Supercritical CO2;Alumina;Aldehyde;Myrtenal