Synthesis and Characterizaion of Biodegradable Crosslinked Copolyesters: Poly(1,4-butanediol-co-malate)s

Yong Kiel sung; Seung Jun Han

Korea Polymer Journal, Vol.7, No.1, 1-5, February, 1999

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Synthesis and Characterizaion of Biodegradable Crosslinked Copolyesters: Poly(1,4-butanediol-co-malate)s

Yong Kiel sung^†, and Seung Jun Han

Department of Chemistry, Dongguk University, Seoul 100-715, Korea

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The biodegradable crosslinked poly(1,4-butanediol-co-L-malate)s(XL-PBLMs) were synthesized using Krebs cycle acids for biomedical applications. The synthesized copolyesters were indentified by FT-IR spectrophotomer. The glass transition temperatures of XL-PBLMs were 3.3℃ in XL-PBLM10, 3.9℃ in XL-PBM12, and 4.9℃ in XL-PBLM14, respectively. The swelling ratios of the crosslinked copolyesters were measured in various pH aqueous solutions at 37℃. The swelling degrees of the crosslinked copolyester increased in the order of XL-PBLM12 XL-PBLM14XL-PBLM12>XL-PBLM14.

[References]

Zhang X, Goosen MFA, Wyss UP, Pichora D, J. Macromol. Sci.-Rev. Macromol. Chem. Phys., C33(1), 81 (1993)
Vert M, Ohabot F, Christel P, Macromol. Chem. Suppl., 5, 30 (1981)
Hoffmann AS, J. Appl. Polym. Sci. Appl. Polym. Symp., 31, 313 (1977)
Kim SW, Petersen RV, Feijen J, Drug Design, E.J. Ariens, Ed., Academic Press, New York, vol. 6, pp. 193 (1980)
Langer R, Peppas N, J. Macromol. Sci.-Rev. Macromol. Chem. Phys., C23, 61 (1983)
Ahn KD, Kwon IC, Kim YH, Polym.(Korea), 11(2), 97 (1987)
Kumar GS, Kalpagam V, Nandi US, J. Macromol. Sci.-Rev. Macromol. Chem. Phys., C22(2), 225 (1982)
Hocking PJ, J. Macromol. Sci.-Rev. Macromol. Chem. Phys., C32, 35 (1992)
Cohn D, Younes H, J. Biomed. Mater. Res., 22, 99 (1988)
Mayer JM, Kaplan DL, Trends Polym. Sci., 2(7), 227 (1994)
Braud C, Bunel C, Garreau H, Vert M, Polym. Bull., 9, 198 (1983)
Carou A, Braud C, Bunel C, Vert M, Polymer, 31, 1797 (1983)
Ouchi T, Fujino A, Macromol. Chem., 190, 1523 (1989)
Ouchi T, Kobayashi H, Bunda T, Br. Polym. J., 23, 221 (1990)
American Society for Testing, and Materials ASTM DG21-70 (1985)
Annual Book of Standards, ASTM, Philadelpia, Pa., 1052 (1985)

[Referenced By]

[1] Zhang X, Goosen MFA, Wyss UP, Pichora D, J. Macromol. Sci.-Rev. Macromol. Chem. Phys., C33(1), 81 (1993)

[2] Vert M, Ohabot F, Christel P, Macromol. Chem. Suppl., 5, 30 (1981)

[3] Hoffmann AS, J. Appl. Polym. Sci. Appl. Polym. Symp., 31, 313 (1977)

[4] Kim SW, Petersen RV, Feijen J, Drug Design, E.J. Ariens, Ed., Academic Press, New York, vol. 6, pp. 193 (1980)

[5] Langer R, Peppas N, J. Macromol. Sci.-Rev. Macromol. Chem. Phys., C23, 61 (1983)

[6] Ahn KD, Kwon IC, Kim YH, Polym.(Korea), 11(2), 97 (1987)

[7] Kumar GS, Kalpagam V, Nandi US, J. Macromol. Sci.-Rev. Macromol. Chem. Phys., C22(2), 225 (1982)

[8] Hocking PJ, J. Macromol. Sci.-Rev. Macromol. Chem. Phys., C32, 35 (1992)

[9] Cohn D, Younes H, J. Biomed. Mater. Res., 22, 99 (1988)

[10] Mayer JM, Kaplan DL, Trends Polym. Sci., 2(7), 227 (1994)

[11] Braud C, Bunel C, Garreau H, Vert M, Polym. Bull., 9, 198 (1983)

[12] Carou A, Braud C, Bunel C, Vert M, Polymer, 31, 1797 (1983)

[13] Ouchi T, Fujino A, Macromol. Chem., 190, 1523 (1989)

[14] Ouchi T, Kobayashi H, Bunda T, Br. Polym. J., 23, 221 (1990)

[15] American Society for Testing, and Materials ASTM DG21-70 (1985)

[16] Annual Book of Standards, ASTM, Philadelpia, Pa., 1052 (1985)