This paper explores the application of the fuzzy logic for risk assessment of major hazards connected with transportation of flammable substances in long pipelines. As a basis for risk assessment, the framework of the fuzzy Layer of Protection Analysis (fLOPA) was used. fLOPA presents a new approach to risk assessment based on two assumptions: 1. different effects of the layer of protection functions on particular elements of the risks (frequency and severity of consequence), and 2. the application of fuzzy logic system (FLS) composed of three elements: fuzzification, inference process and defuzzification. A further calculation follows LOPA methodology with the use of fuzzy logic system where fuzzy risk matrix is used for risk assessment. A typical case study comprising section of a long pipeline failure is performed and a comparison between the classical LOPA approach and fuzzy approach is made. (C) 2009 Elsevier Ltd. All rights reserved.