Synthesis and Characterization of Temperature Sensitive Poly(organophosphazene)Hydrogels

Kim Y; Park DS; Yim G; Shim BC; Kim JH; Lee DS

Korea Polymer Journal, Vol.6, No.5, 381-388, December, 1998

Kim Y, Park DS, Yim G, Shim BC, Kim JH, Lee DS

Poly(organophosphazene)s bearing a hydrophilic group, 2-(2-methoxyethoxy)ethoxy and a hdrophobic group such as methyl ester of alanine, 2,2,2-trifluoroethoxy, benzyloxy and p-(2-(2methoxyethoxy)ethoxyphenyl)phenoxy were synthesized and characterized by NMR spectroscopy, differential scanning calorimeter, gel permeation chromatography, and elemental analysis. These polymers were crosslinked by irradiating UV light in the presence of benzophenone or irradiating gamma ray (3M rad). Gamma radiation crosslinked the polymers but significant decomposition took place simultaneously. Polymers crosslinked by UV irradiation formed integrate hydrogels when swollen with water. Polymers containing hydrophobic groups in high fractions formed hydrogels without crosslinking. All the hydrogels prepared in this study had lower critical solution temperatures as the hydrogels became clouds as the temperature was raised. Tjhe volume change at the clouding point varied depending on the nature of the side groups, compositio, and the amount of water in the hydrogel. The volume change at the clouding point was negligible for most hydrogels investigated in this study.

[References]

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[1] Siegel RA, Pulsed and Self-Regulated Drug Delivery, CRC Press, Boca Raton, FL., Chapter 8 (1990)

[2] Brannon-Peppas L, Peppas NA, Chem. Eng. Sci., 46, 715 (1991)

[3] Feil H, Bae YH, Feijen J, Kim SW, J. Membr. Sci., 64, 283 (1991)

[4] Dong LC, Hoffman AS, J. Control. Release, 13, 21 (1990)

[5] Yoshida R, Uchida K, Kaneko Y, Sakai K, Kikuchi A, Sakurai Y, Okano T, Nature, 374(6519), 240 (1995)

[6] De Rossi D, Suzuki M, Osada Y, Morasso P, J. Intell. Mater. Syst. Struct., 3, 75 (1992)

[7] Kaetsu I, Uchida K, Morita Y, Okubo M, Radiat. Phys. Chem., 40, 157 (1992)

[8] Tanaka T, Nishio I, Sun ST, Ueno-Nishio S, Science, 218, 467 (1982)

[9] Kwon IC, Bae YH, Kim SW, Nature, 354, 292 (1991)

[10] Hooper HH, Baker JP, Blanch HW, Prausnitz JM, Macromolecules, 26, 1761 (1993)

[11] Ohmine I, Tanaka T, J. Chem. Phys., 77, 5725 (1982)

[12] Inomata H, Goto S, Otake K, Saito S, Macromolecules, 8, 687 (1992)

[13] Hu Y, Horie K, Ushiki H, Yamashita T, Tsunomori F, Macromolecules, 26, 1761 (1993)

[14] Amiya T, Tanaka T, Macromolecules, 20, 1162 (1987)

[15] Okuzaki H, Osada Y, Proceedings of the First International Conference on Intelligent Materials, Technomic Publishing Co., Inc., Lanaster, PA, pp. 273-278 (1993)

[16] Sawahata K, Hara M, Yasunaga H, Osada Y, J. Control. Release, 14, 253 (1990)

[17] Susuki A, Proceedings of the First International Conference on Intelligent Materials, Technomic Publishing Co., Inc., Lanaster, PA, pp. 297-300 (1993)

[18] Mamada A, Tanaka T, Kungwatchakun D, Irie M, Macromolecules, 23, 1517 (1990)

[19] Lee K, Cussler EL, Marchetti M, McHugh MA, Chem. Eng. Sci., 45, 766 (1990)

[20] Wichterle O, Lim D, Nature, 185, 117 (1960)

[21] Allcock HR, Austin PE, Neenan TX, Sisko JT, Blonsky PM, Shriver DF, Macromolecules, 19, 1508 (1986)

[22] Blonsky PM, Shriver DF, Austin PE, Allcock HR, Solid State Ion., 18, 258 (1986)

[23] Allcock HR, Dudley GK, Macromolecules, 29(4), 1313 (1996)

[24] Allcock HR, Adv. Chem. Ser., 248, 1 (1994)

[25] Kim YB, Cho CH, Hong SY, Polym.(Korea), 20(2), 163 (1996)

[26] Feil H, Bae YH, Feijen J, Kim SW, Macromolecules, 26, 2496 (1993)

[27] Gutowska A, Bae YH, Jacobs H, Feijen J, Kim SW, Macromolecules, 27(15), 4167 (1994)