This paper presents details of an integrated inherent safety index (I2SI). The conceptual framework of this index was presented at the 37th Annual Loss Prevention Symposium of the AIChE (2003) and published in Process Safety Progress (volume 23(2), 136-148, 2004). In addition to the framework, the current paper discusses additional features of the index such as the cost model and system design model, which were not presented or discussed earlier. I2SI is called an integrated index because the procedure considers the life cycle of the process with economic evaluation and hazard potential identification for each option. I2SI is comprised of sub-indices which account for hazard potential, inherent safety potential, and add-on control requirements. In addition to evaluating these respective characteristics, there are also indices that measure the economic potential of the option. To demonstrate the applicability and efficacy of I2SI, an application of the index to three acrylic acid production options is also discussed in the paper. (c) 2005 Elsevier Ltd. All rights reserved.