In this paper, response surface methodology (RSM) approach using Central Composite Design (CCD) is applied to develop mathematical model and optimize process parameters for Cr (VI) removal from aqueous streams using weakly anionic resin Amberlite IRA 96. The individual and combined effect of four process parameters, i.e. contact time, initial solution pH, initial Cr (VI) concentration and resin dose on Cr adsorption were studied. Analysis of variance (ANOVA) showed the relative significance of process parameters in removal process. Initial solution pH and resin dose were found to be more significant than contact time and initial Cr (VI) concentration. The second-order regression model was developed to predict the removal efficiency using Design Expert software. The optimal conditions to remove Cr from aqueous solution at constant temperature of 30 degrees C and stirring speed of 250 rpm were found to be contact time 62.5 min, pH 1.96, initial Cr (VI) concentration 145.4 mg/L, and resin dose 8.51 g/L. At these conditions, high removal efficiency (93.26%) was achieved. FTIR and EDX analysis were conducted to interpret the functional groups involved during the Cr-resin interaction. (C) 2012 Elsevier B.V. All rights reserved.