Spray incineration and supercritical water oxidation (SCWO) processes have been used for detoxifying waste organic fluids in the University of Tokyo. In this study, we aim to elucidate the environmental aspects of these waste treatment processes by life cycle assessment (LCA). Through the investigation of actual plants, the inventory data and other characteristics of actual plants were collected and analyzed. To confirm the potential of SCWO, three modification types of the process and operation were considered and assessed on the basis of estimated inventory data. The results demonstrate that spray incineration has less environmental impact than SCWO in all scenarios. However. SCWO has various advantages for installation as a treatment process in universities such as negligible risk of creating dioxins and particulate matter. Proper choice of the treatment method for organic waste fluid requires a comprehensive analysis of risks. Spray incineration poses the risk of providing dioxins and particulate matter, while SCWO has such risk at negligible level. This means that waste including concerned materials related to such emission should be treated by SCWO. Using the right technologies for the right tasks in the detoxification of hazardous materials should be implemented for sustainable universities. (C) 2011 Elsevier B.V. All rights reserved.