Food industry is the first in European Community for revenues, with more than 8 millions of employee. Logistics and supply chain management play a crucial role in food industry. This paper presents a general and conceptual framework for the assessment of food supply chain (FSC) and logistics of food products in agreement with a multidisciplinary and integrated view. The target of the proposed integrated approach to supply chain design and management is the simultaneous control of quality (1), safety (2), sustainability (3) and logistics efficiency (4) of food products and processes along the whole FSC "from farm to fork". A case study focused on package design, distribution issues, and supported by the development of an original close-loop control system is a first exemplifying step towards a new integrated approach on FSC assessment in agreement with the proposed conceptual framework. Finally, the paper presents a discussion on the most important challenges in FSC for public and private research in industry and in academic institutions. (C) 2012 Elsevier Ltd. All rights reserved.