Characteristics of Hydrophobic-Hydrophilic Multiblock Copolymers

Kim YJ; Sung YK; Pial AZ; Kim SW

Korea Polymer Journal, Vol.5, No.4, 214-220, December, 1997

ABCBA type amphiphilic block copolymers comprising poly(dimethyl siloxane), poly (ethylene oxide), and heparin segments were synthesized by coupling reactions between in-termediate and end-functionalized oligomers. These multiblock copolymers were identified using ₁H-NMR and FR-IR. The compositions of synthesized block copolymers were determined by end group analysis, sulfur elemental analysis, and integration of NMR signals. The degrees of swelling of the multiblock copolymers increased by increasing the molecular weight of PEO in water. By utilizing Wilhelmy plate plate contact angle measurement and electron microscopy, the surfaces of the block copolymers were characterized. Contact angle measurements demonstrated the hydrophilic effect of PEO and heparin on the hysteresis of the block copolymers and the heparinized block copolymers.

[References]

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Kim YJ, Sung YK, Piao AZ, Grainger DW, Okano T, Kim SW, J. Appl. Polym. Sci., 54(12), 1863 (1994)
Andrade JD, Smith L, Gregonis DE, Contact Angle and Interface Energetics, in Surface andn Interfacial Aspects of Biomedical Polymers, J.D. Andrade, Ed., Plenum Press, New York, NY, vol. 1 (1985)

[1] Noshay A, McGrath JE, Block Copolymers, Overview and Critical Survey, Academic Press, New York (1977)

[2] Matsue M, Sagaye S, Micromorphology-Property Relationships in Graft and Block Copolymers, in Colloidal and Morphological Behavior of Block Copolymers, Ed., G.E. Molau, Plenum Press, New York (1977)

[3] Okano T, Nishiyama S, Shinohara J, Akaike T, Sakurai Y, Kataoka K, Tsuruta T, J. Biomed. Mater. Res., 15, 391 (1981)

[4] Okano T, Katayama M, Shinohara I, J. Appl. Polym. Sci., 22, 369 (1987)

[5] Okano T, Aoyagi T, Kataoka K, Abe K, Sakurai Y, Shimada M, Shinohara I, J. Biomed. Mater. Res., 20, 919 (1986)

[6] Vulic I, Okano T, Kim SW, Feijen J, J. Polym. Sci. A: Polym. Chem., 26, 381 (1988)

[7] Davanthan T, Sluetz JE, Young KA, Biomater. Med. Dev. Art. Org., 8, 4 (1980)

[8] Ratner BD, Biomedical Applications of Hydrogels: Review and Critical Application, in Biocompatibility of Clinical Implant Materials, D.F. Williams, Ed., CRC Press (1981)

[9] Sung YK, Grainger DW, Okano T, Feijen J, Kim SW, IUPAC Int. Symposium on Macromol., Preprints, p. 588 (1988)

[10] Kim YJ, Sung YK, Piao AZ, Grainger DW, Okano T, Kim SW, J. Appl. Polym. Sci., 54(12), 1863 (1994)

[11] Andrade JD, Smith L, Gregonis DE, Contact Angle and Interface Energetics, in Surface andn Interfacial Aspects of Biomedical Polymers, J.D. Andrade, Ed., Plenum Press, New York, NY, vol. 1 (1985)