Gd-Ba-Cu-O (GdBCO) bulk superconductors of diameter of 42 mm have been fabricated via a multi-seeded melt growth (MSMG) method in air using well-oriented Nd-Ba-Cu-O thin film seeds. The effect of seed orientation on the growth process and the formation of grain boundaries were investigated systematically by using two thin film seeds arranged with crystallographic orientations of (100)/(100) and (110)/(110), respectively. The multi-seeded process was then firstly extended to four thin film seeds arranged asymmetrically [(110)/(110)], which involved placing the seeds in pairs, with two adjacent seeds positioned relatively close to each other and the other two at a greater separation. This modified technique is beneficial to obtain a large size GdBCO bulk in a shorter time as well as clean grain boundaries by rejecting the excess melt liquid thoroughly along the growth front. More interestingly, a domain of non-equilibrium shape is formed during the MSMG process, which leads potentially to the growth of much larger samples. The growth mode of the enhancement in growth rate is interpreted by the presence of a high index crystallographic (110) face to the initial growth front. Crown Copyright (C) 2013 Published by Elsevier B.V. All rights reserved.