The binding interactions between cationic surfactants and a statistical thermo-sensitive copolymer based on oligo(ethylene glycol) methacrylates were studied by isothermal titration calorimetry (ITC), surfactant selective electrode (SSE) and dynamic light scattering (DLS). Strong binding interactions were observed between this copolymer and cationic surfactants. The binding is driven by the hydrophobic effect, occurring on the hydrophobic backbone instead of the ethylene-glycol side chains. The surfactant saturation concentration C-2 depended on the polymer concentration, but was not affected by temperature. Three types of cationic alkyltrimethylammonium bromide surfactants (RTAB with R equal to C-12, C-14, and C-16), namely, dodecyltrimethylammonium bromide (DoTAB), tetradecyltrimethylammonium bromide (TTAB), and cetyltrimethylammonium bromide (CTAB), were examined, and the results confirmed that the binding affinity followed the sequence: (TAB > TTAB > DoTAB. (C) 2013 Elsevier Inc. All rights reserved.