Architected nanostructures with interior space have attracted enormous attention due to both their esthetic beauty and their potential applications. It is a current dream to develop a template-free, one-pot and low-temperature synthetic routes for hetero-architecture in liquid media. In this manuscript, we develop a kind of template-free, low-temperature, and one-pot total synthetic strategy for synthesis of inorganic multi-component hetero-architecture. This synthetic strategy analogous to standard organic reactions used in total synthesis is an important breakthrough in inorganic chemical synthesis. We can achieve 1 kilogram (kg) yield of the TiO2@void@SiO2 core-shell sphere one time by using this synthetic strategy, which may lead to practical applications of the sample. By embodying the new reaction and concept into future investigation, a more mature research field in synthetic architecture of nanomaterials can be anticipated. (C) 2011 Elsevier Inc. All rights reserved.