The development, fabrication, and testing of a compact multiplexed system of electrosprays are presented with the dual goal of increasing by orders of magnitude the liquid flow rate to be dispersed and of retaining the quasi-monodispersity of the generated droplets. The system was microfabricated as an array of nozzles etched in silicon, with a density of 250 sources/cm(2). Although the operation of a single electrospray is rather forgiving with respect to the electrode geometry, successful performance of the multiplexed system is critically dependent on a careful selection of the electrode configuration, which in the present work entails an extractor electrode mounted at a distance from the spray sources that is comparable to the distance between sources (on the order of 0.5 mm). The electrode has the dual function of limiting electric field cross-talk between neighboring sources and minimizing space charge feedback from the spray cloud. Measurements of current and droplet size as a function of flow rate and of droplet size distribution using ethanol demonstrated that the system may be optimized to produce uniform droplets simultaneously from all parallelized electrosprays, each one operating as an isolated spray in the quasi-monodisperse cone jet mode. Ease of operation and uniformity in size from spray to spray require strategies to increase the pressure drop in the liquid flow path and/or to uniformize the electric field at the spray sources. (c) 2005 Elsevier Ltd. All rights reserved.