This work provides experimental data on thermophoretic deposition of submicron aerosols (2 < Kn < 30) in laminar tube flow at temperatures of 400-600 degrees C and gas-to-wall temperature differences of 300-400 degrees C. This range is significantly higher than in previous experiments and of technical interest. Fluid flow in a cylindrical tube as well as aerosol transport and deposition in the thermal gradient were simulated using a CFD computer code (Fluent) and the Talbot expression for the thermophoretic velocity, with the thermophoretic coefficient alpha(t) as a fit parameter. it was found that a constant value of alpha(t) = 0.55 was an acceptable choice for engineering applications, to accurately estimate thermophoretic deposition efficiencies and deposition rates in the range of particle sizes (20-200 nm) and gas temperatures (130-580 degrees C) which were covered in the experiments. (c) 2004 Elsevier Ltd. All rights reserved.