Direct numerical simulation (DNS) and experimental data have shown that inertial particles exhibit concentration peaks in isothermal turbulent boundary layers, whereas tracer-like particles remain well mixed in the domain. It is therefore expected that the interactions between turbulence and thermophoresis will be strong in particle-laden flows where walls and carrier fluid are at significantly different temperatures. To capture turbulent particle dispersion with active thermophoresis, a coupled CFD-Lagrangian continuous random walk (CRW) model is developed. The model uses 3D mean flow velocities obtained from the Fluent 63 CFD code, to which are added turbulent fluid velocities derived from the normalized Langevin equation which accounts for turbulence in homogeneities. The mean thermophoretic force is included as a body force an the particle following the Talbot formulation. Validation of the model is performed against recent integral thermophoretic deposition data in long pipes as well as the TUBA TT28 test with its detailed local deposition measurements. In all cases, the agreement with the data is very good. In separate parametric studies in a hypothetical cooled channel flow, it is found that turbulence strongly enhances thermophoretic deposition of particles with dimensionless relaxation times tau(+) of order I or more. On the other hand, the thermophoretic deposition of very small inertia particles (tau(+) < 0.2) in the asymptotic region far from the injection point tends to that which characterizes stagnant flow conditions, in agreement with the DNS results of Thakurta et al. (C) 2008 Elsevier Ltd. All rights reserved.