In horizontal annular dispersed pipe flow the liquid film at the bottom is thicker and rougher than at the top of the pipe. A turbulent pipe flow experiencing a variation of roughness along the pipe wall will show a secondary flow. Such secondary flow, consisting of two counter-rotating cells in the cross-section of the tube, can change the distribution of the droplets inside the pipe and their deposition at the wall. Here, we compare the behaviour of the droplets (dispersed phase) with and without secondary flow, using large-eddy simulations. It is shown that the presence of secondary flow increases the droplet concentration in the core of the pipe and the droplet deposition-rate at the top of the pipe. (c) 2006 Elsevier Ltd. All rights reserved.